sternocleidomastoid synergist and antagonist

The sternocleidomastoid is innervated by the accessory nerve. Bilaterally: Extend head and neck Unilaterally: Elevate the scapula, downwardly rotate scapula, laterally flex the head and neck, rotate the head and neck, Spinous processes of all vertebrae except C-1, Bilaterally: Extend the vertebral column antagonist; adductor group, gracilis, synergist: hamstring muscles and gracilis Middle: Pectoralis minor, serratus anterior antagonist muscle that opposes the action of an agonist extension an increase in joint angle with movement fixator synergist that assists an agonist by preventing or reducing movement at another joint, thereby stabilizing the origin of the agonist flexion a decrease in joint angle with movement insertion Torticollis. Antagonist: Extensor carpi ulnaris Synergist: sartorious, Action: adducts, flexes and medially rotates thigh Which of the following muscles is not innervated by the median nerve? The two heads are separated from one another at their origins by a triangular interval (lesser supraclavicular fossa) but gradually blend, below the middle of the neck, into a thick, rounded muscle which is inserted, by a strong tendon, into the lateral surface of the mastoid process, from its apex to its superior border, and by a thin aponeurosis into the lateral half of the superior nuchal line of the occipital bone. Synergist: Platysma, Action: Flexes neck forward when together Antagonist: Splenius Which muscles make up the common flexor tendon of the medial epicondyle? Synergist: pectineus, Action: extends knee Which of the following muscles does not attach to the humerus? (a) abductor pollicis longus (b) anconeus and triceps brachii (c) biceps brachii and supinator (d) extensor carpi ulnaris (e) flexor digitorum profundus. a) triceps brachii b) brachialis c) brachioradialis d) coracobrachialis e) anconeus, When the biceps brachii flexes, what is the antagonist? Antagonist: Gracilis a) sternocleidomastoid b) orbicularis oculi c) trapezius d) platysma, Which muscle acts to anchor the scapula? This category only includes cookies that ensures basic functionalities and security features of the website. This muscle binds the skull to the sternum and clavicle. a) Clavicle b) Cervical vertebrae c) Scapula d) Sacrum. For intermediary anatomy students learning skeletal and muscle structure. Antagonist: Sartorious A) Coracobrachialis B) Tricep Brachi C) Latissimus dorsi D) Pectoralis major E) Supraspinatus, Which of the following muscles is an important elevator of the scapula? Sternocleidomastoid: a) used in chewing b) muscle of head or neck c) mandible d) cranium e) atlas f) muscle that move upper extremity g) suicide bags h) epiphysis i) cutaneous j) muscle that move lower extremity. D. The sternocleidomastoid is the fixator and the splenius cervicis is the prime mover. To explain skeletal muscle movements as activities of agonists (prime movers), antagonists, and synergists. Become a Study.com member to unlock this answer! Synergist: deltoid, Action: Forearm flexor Other functions of the SCM include assisting in breathing, maintaining neck posture, and helping the temporomandibular joint (TMJ) function. Antagonist: Gluteus maximus (a) Auricular. [3][4] The sternocleidomastoid is thick and narrow at its centre, and broader and thinner at either end. 1 What is the synergist muscle for sternocleidomastoid? 3 What is the antagonist muscle in elbow flexion? Some studies have indicated a supernumerary cleido-occipital muscle more or less separate from the sterno-cleido-mastoid muscle. Antagonist: Gracilis M. lavish It can also occur with certain health conditions, such as asthma and. The t-tubule meets with the sarcoplasmic reticulum at locations throughout the muscle fiber, at these locations the sarcoplasmic reticulum releases calcium ions that results in the movement of troponin and tropomyosin on thin filaments. Antagonist: adductor mangus Scalenes, opposite side of splenius capitis, Anterior,Medial, and Posterior Transverse Processes of the Cervical Vertabrae, Bilaterally: Elevate the ribs during Inhalation (ALL), Posterior neck muscles/ extensors opposite scalenes, External occipital protuberance, medial portion of superior nuchal line of the occiput. Which of the following muscles is most active during lateral rotation of the arm? a. soleus b. tibialis anterior c. flexor digitorum longus d. gracilis e. extensor digitorum brevis, Which shoulder joint muscle is associated with humeral abduction, flexion, horizontal adduction, and internal rotation? Read more, Physiopedia 2023 | Physiopedia is a registered charity in the UK, no. Bilateral SCM muscle contraction thrusts the chin forward when your head is level. Synergist: Splenius, Action: adducts and medially rotates arm Middle: Adduct the scapula, stabilize the scapula Etymology and location [ edit] Which of the following muscles is (only) responsible for scapular protraction and upward rotation? Which of the following muscles is a rotator cuff muscle? Sternocleidomastoid Function with and without the Longus Colli. The antagonist of the splenius capitis muscle is the Sternocleidomastoid. All other trademarks and copyrights are the property of their respective owners. (a) biceps brachii (b) triceps brachii (c) jaw (d) tongue. This muscle is innervated by the spinal accessory nerve (cranial nerve 11). Treatment for this involves strengthening exercises for the SCM muscle, and repair of the nerve if possible. A. biceps brachii B. brachialis C. brachioradialis D. triceps brachii, Which of the following muscles is a developmentally dorsal muscle of the upper limb? When Marta and her family taked(1)\overset{\text{(1)}}{{\underline{\text{taked}}}}taked(1) a vacation in Australia, they are(2)\overset{\text{(2)}}{{\underline{\text{are}}}}are(2) surprised at how the time changed during their airline flights across the Pacific Ocean. Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. Antagonist: Temporalis For example, the scalenes are synergist muscles to the sternocleidomastoids (SCM), because they help with turning and tilting the head and neck. Structure [ edit] A few fibers of the SCM insert at the bottom of the. kleine weie friedenstaube text und noten. B), Which large muscle has an attachment on the external occipital protuberance and extends the neck? The form of a muscle that stabilizes the origin of the prime mover so that it can act more efficiently is called the: a. synergist b. agonist c. antagonist d. fixator e. secondary mover The muscles of ____ lie within the subcutaneous layer, originating on the fascia or bones of the _____ and inserting into the _____. The movement of troponin and tropomyosin is key in facilitating the myosin head to move along the thin filament, resulting in a contraction of the sternocleidomastoid muscle. E. The. This condition when present in humans is considered to be a variation from normal. Our vessels consisted of six small canoes, and two large (1) pirogues. We were now about to penetrate a country at least two thousand miles in width, on which the foot of civilized man had never (3) trodden; the good or evil it had in store for us was for experiment yet to determine, and these little vessells contained every article by which we were to expect to (4) subsist or defend ourselves. Which of the following muscles is most active during extension of the arm/glenohumeral joint? What muscle(s) serves as an antagonist to the biceps? Read the flipbook version of Seeleys essentials of anatomy physiology ( etc.). In a back extension these muscles are the agonist. The world divides(7)\overset{\text{(7)}}{{\underline{\text{divides}}}}divides(7) into 242424 time zones so that the sun is high in the sky at noon almost everywhere on earth. (a) Brachialis (b) Pronator quadratus (c) Biceps brachii (d) Supinator. Which muscle depresses the clavicle and stabilizes the pectoral girdle? Sternal Head:Upper part of the anterior surface of the manubrium Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet. a. Biceps brachii b. Triceps brachii c. Jaw d. Tongue. By working to keep good posture and gently stretch and strengthen the SCM and other muscles around your neck, you can experience improvement of symptoms associated with the SCN. Muscles Testing and Function with Posture and Pain. Antagonist: external intercostals B. The major muscles of the neck include the semispinalis capitis, splenius capitus, levator scapulae, scalenes, trapezius, sternohyoid, onohyoid, and the sternocleidomastoid. a. Levator scapulae b. Pectoralis minor c. Rhomboid d. Serratus anterior e. Trapezius, Which of the following muscles is a rotator cuff muscle? Read the entire passage once to get a general idea of what it is about. L. languish It is thick and thus serves as a primary landmark of the neck, as it divides the neck into anterior and posterior cervical triangles (in front and behind the muscle, respectively) which helps define the location of structures, such as the lymph nodes for the head and neck.[8]. Underline nouns or pronouns that make up each one. An excellent book for those beginning the study of anatomy. antagonist: hamstring muscles, synergist: adductor muscles, gracilis It is shown that localized muscle pain can reorganize the EMG activity of synergists where no pain is present, and this findings may have implications for the understanding of manifestations seen in relation to painful musculoskeletal disorders. Synergist: NA, Action: Only flexor of distal phalanges [3] It also flexes the neck. The function of this muscle is to rotate the head to the opposite side or obliquely rotate the head. The mutual links between muscle pain and resting electromyographic (EMG) activity are still controversial. We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. Use each word once. Synergist: Sartorious, Action: Powerful hip extensor antagonist: tensor fasciae latae, gluteal minimus, medius muscles, synergist: gastrocnemius E. Scalenes. What is the function of the sternocleidomastoid muscles? It travels superiorly, laterally, and posteriorly. The muscle that is contracting is called the agonist and the muscle that is relaxing or lengthening is called the antagonist. During elbow flexion where the bicep is the agonist, the tricep muscle is the antagonist. Antagonist: Synergist: flexor carpi ulnaris, Action: adducts hand Ligamentum nuchae and spinous processes of C7-T12, Lateral 1/3 of clavicle, Acromion Process and spine of the scapula, Upper: Bilaterally- Extend the head and neck Synergist: NA, Action: Planatar flexion when knee is extended Synergist: Gastrocnemius, Action: Flexes and rotates medially The time in the first time zone east of the date line is 232323 hours earlier than the time in the first time zone to the west. the old post office chicago wedding cost; how does synaptic wiring allow the brain to learn memorize and change; how old was oakes fegley in the goldfinch lake mary ca water temperature synergist and antagonist muscles. However, as the state of mind in which we are, generally gives the (5) colouring to events, when the imagination is (6) suffered to wander into futurity, the picture which now presented itself to me was a most pleasing one. Synergist: Pronator teres, Action: Extends and abducts wrist Origin vs. insertion b. Intrinsic vs. extrinsic c. Agonist vs. antagonist 2. Antagonist: pectoralis major Synergist: pectoralis major, Action: Flexes wrist and middle phalanges Frowning (antagonist of zygomaticus) Orbicularis oris Indirectly from maxilla/mandible, fibers blend. for free. Bilaterally: Stabilizes the head, flexion of the head and neck, checkreins backwardmotion of the head and neck, Innervation:Accessory nerve: cranial nerve XII and ventral rami of the (C2, C3), Blood Supply:Branches from the vertebral artery, 1. We also use third-party cookies that help us analyze and understand how you use this website. Antagonist: Psoas d) biceps brachii. What are various methods available for deploying a Windows application? Drug combinations may exhibit synergistic or antagonistic effects. F. edifice These cookies will be stored in your browser only with your consent. The platysma muscle is a superficial muscle of the human neck that overlaps the sternocleidomastoid. Synergist: vastus lateralis, Action: extends knee C. The sternocleidomastoid is the prime mover and the splenius cervicis is the antagonist. (adsbygoogle = window.adsbygoogle || []).push({}); For Pain and Symptom Information See: Sternocleidomastoid Muscles: Head, Eyes, Sinus, Ears, Throat Pain. C. censure Also, the muscle works with the scalene muscles in the neck during forced inspiration while breathing. Antagonist: Extensor digitorium longus Muscle agonists. Muscles that Act on the Scapula . By Anne Asher, CPT Insert a caret (^) to show where the word only should be placed to match the meaning in parentheses. But opting out of some of these cookies may affect your browsing experience. A. Biceps brachii B. Brachialis C. Brachioradialis D. Triceps brachii, Which of the following muscles provides the greatest contribution to lateral rotation of the shoulder joint? Action: Pulls ribs forward synergist that assists an agonist by preventing or reducing movement at another joint, thereby stabilizing the origin of the agonist flexion movement that decreases the angle of a joint fulcrum an axis of rotation, like a joint fusiform muscle that has fascicles that are spindle-shaped to create large bellies insertion https://www.kenhub.com/en/library/anatomy/sternocleidomastoid-muscle, https://www.youtube.com/watch?v=eD3Ds3GIt9M, https://www.physio-pedia.com/index.php?title=Sternocleidomastoid&oldid=299309, a medial rounded and tendinous sternal head (SH). c) pectoralis major. Antagonist: Pronator teres Which of the following muscles is part of the rotator cuff? Antagonist: Tensor fascia latae Six heads of origin of sternocleidomastoid muscle: a rare case. The SCN can produce several different neck movements. A. rectus abdominis B. transversus abdominis C. erector spinae D. latissimus dorsi. Antagonist: gluteus maximus 2023 Dotdash Media, Inc. All rights reserved. It also flexes the neck. As they ascend, the CH spirals behind the SH and blends with its deep surface below the middle of the neck, forming a thick rounded belly. Sternocleidomastoid and the Scalenes are Synergists, which mean that they work together to provide the same movements (flexion, rotation and lateral flexion of the head and neck)An Antagonist. Synergist: Gracilis, Action: Prime mover of foot inversion (a) Teres major (b) Triceps brachii (c) Pectoralis major (d) Latissimus dorsi. In this situation, the SCM also turns the face upward just a little, adding in a bit of neck extension. Get access to this video and our entire Q&A library. The sternocleidomastoid is innervated by the accessory nerve . I give my consent to Physiopedia to be in touch with me via email using the information I have provided in this form for the purpose of news, updates and marketing. Middle deltoid c. Posterior deltoid d. Superior deltoid, Which shoulder joint muscle is associated with humeral abduction, flexion, horizontal adduction and internal rotation? Contralateral rotation of the head and cervical spine when acting unilaterally. Synergist: deltoid, Action: lateral rotation of humerus Examination of the sternocleidomastoid muscle forms part of the examination of the cranial nerves. The SCM continues on to attach to the mastoid bone. Furthermore, they are components of the boundaries of the submental and submandibular triangles of the neck. Antagonist: Soleus Occasionally, the lower portion of the SCM muscle is intercepted by tendinous intersections which indicate the origin of this muscle from different myotomes .The organizational pattern of the SCM can be arranged into five distinct topographical parts, namely the superficial sternomastoid, profound sternomastoid, sterno occipital, cleidomastoid and cleidooccipital parts which are arranged in superficial and deep layers. (a) Deltoid (b) Teres major (c) Infraspinatus (d) Coracobrachialis (e) Trapezius. Antagonist: gastrocnemius The occurrence of such a variation can be explained by fusion failure or abnormal mesodermal splitting during development. Antagonist: Sternocleidomastoid; Longus colli and capitis; Scalenus anterior, . The frequency of cleido-occipital muscle occurrence has been reported up to 33%. The longus colli is a deep cervical flexor acting as an important synergist with the sternocleidomastoid muscle. Developmentally, these additional muscle slips indicate abnormal mesodermal splitting in posterior sixth branchial arch. antagonist: adductor group, gracilis, synergist: gluteus medius, gluteus minimus, gluteus maximus Which of the following muscles is primarily a postural muscle? (a) diaphragm (b) triceps brachii (c) pronator teres (d) flexor carpi ulnaris (e) extensor indicis. (a) What does the king specify as his wish for Mari Djata? Kendall, Florence Peterson, McCreary, Elizabeth Kendall, and Provance, Patricia Geise. For example, when you rotate or turn your head to the right, your left SCM is contracting. D. The sternocleidomastoid is the fixator and the splenius cervicis is the prime mover. What experience do you need to become a teacher? Lower: Levator Scapulae. The primary actions of the muscle are rotation of the head to the opposite side and flexion of the neck. Synergists and Antagonists Synergists - are groups of muscles working together to cause movement The positive effects of physical activity and exercise on almost all functions of the human body are widely acknowledged. Antagonist: Tibialis posterior This can cause atrophy (shrinking) in the affected SCM and may cause difficulty in turning the head and bending the neck. The Anatomy of the Brachiocephalic Artery, Superficial Layer of the Intrinsic Back Muscles, Causes of Collarbone Pain and Treatment Options, Hamstring Muscles: Anatomy, Function, and Common Injuries, spinal accessory nerve (cranial nerve 11), Anatomy, head and neck, sternocleidomastoid muscle. - a synergist - an antagonist - a fixator - a prime mover - an antagonist. They act to extend the spine, bending it backwards. In the blank, insert the most appropriate word. Together they allow normal posturing of the head and neck referred to as an "elongated neck with chin tuck." Together, these muscles provide flexion of the elongated . Synergist: psoas, Action: adducts thigh Muscles and nerves MBLEx. Moore, Keith, L., Dalley, Arthur, F. Clinically Oriented Anatomy. Benign fibrosis, hypoplasia or aplasia of SCM is the most common cause of congenital torticolis. The sternocleidomastoid muscles flex the neck and the splenius cervicis muscles extend it. You also have the option to opt-out of these cookies. Capt. Get Top Tips Tuesday and The Latest Physiopedia updates, The content on or accessible through Physiopedia is for informational purposes only. The International Date Line lays(8)\overset{\text{(8)}}{{\underline{\text{lays}}}}lays(8) between two time zones in the Pacific Ocean. D. Pectoralis minor. Synergist: Brachioradialis, Action: Extends thumb A coexisting unilateral absence of SCM with the ipsilateral absent trapezius is an extremely rare variation and till date, only about three such reports are present in literature .Such cases present with cosmetic and functional impairment and are best diagnosed by Magnetic Resonance Imaging scans. Which muscle acts as an agonist with the teres minor during lateral rotation of the shoulder? The splenius captis is located on the lateral side of the C7. antagonist: trapezius, latissimus dorsi, rhomboids, pectoralis major, antagonist: biceps brachii and brachialis, synergist: brachialis Synergist muscles help other muscles perform one or more functions. It is partially covered by the gluteus maximus. Synergist: Psoas, Action: stabilizes pelvis Antagonist: Palmaris longus Sternocleidomastoid (SCM) muscle pain in the neck typically results from muscle tension or performing repeated motions. Which of the following muscles is most active during flexion of the arm/glenohumeral joint? During elbow flexion where the bicep is the agonist, the tricep muscle is the antagonist. e) platysma. d. Splenius. d) occipitalis. Synergist: adductor longus, Action: adducts, flexes and medially rotates thigh Michael Menna, DO, is a board-certified, active attending emergency medicine physician at White Plains Hospital in White Plains, New York. Identify the word in given pair that is spelled correctly. Sternocleidomastoid (Action, Synergist, Antagonist, BodyBuilder (Y/N)) Action: Flexes or Rotates the Head Synergist: N/A Antagonist: N/A BodyBuilder: Yes . The cervical plexus supplies sensation, including proprioception, from the ventral primary rami of C2 and C3.[5]. last ten years, I could but esteem this moment of my departure as among the most happy of my life. Coloring helps memory retention. Available from: T Hasan. (a) sternocleidomastoid (b) splenius capitis (c) semispinalis cervicis (d) scalenus anterior. It can be felt on each side of the neck when a person moves their head to the opposite side. Which of the following does not attach to the corocoid process of the scapula? The accessory nerve nucleus is in the anterior horn of the spinal cord around C1-C3, where lower motor neuron fibers mark its origin. Muscles that work like this are called antagonistic pairs. Synergists (Neutralizers): Muscles that contract to assist the prime movers, either by: adding force to the movement and making it more refined Or . sternocleidomastoid synergist and antagonist Synergist muscles work along with agonist muscles to create motion analogous to or in conjunction with agonist muscles, allowing for a wide range of conceivable motions. The muscle that is contracting is called. 2 What muscle is behind the sternocleidomastoid? Unilaterally: Rotation of head to the opposite side, lateral flexion of the neck on the same side A neck extension movement that takes place at your first. a) trapezius b) levator scapula c) serratus anterior d) latissimus dorsi. The other muscles in the anterolateral neck flexor group are the scalenes, which are located more deeply in the neck than the SCM. A. appall The deep muscles of the neck, levator scapulae and middle scalene muscle are supplied by which nerve? Synergist: abductor pollicis longus, Action: Flexed thumb Antagonist: Flexor carpi ulnaris A) The sternocleidomastoid is the prime mover, and the splenius cervicis is the fixator. Antagonist: Scalenes Synergist or Antagonist DRAFT. Describe how the prime move Synergist: pectoralis major, Action: Extends and medially rotates humerus Excellent visuals! a) frontalis. Synergist: Gluteus maximus, Action: Extends thigh and flexes knee Synergist: Gastrocnemius, Action: Prime mover of dorsiflexion to invert foot Synergist: Sarotious, Action: Abducts and medially rotates thigh In the case of the sternocleidomastoid muscle, it is innervated by the accessory nerve (cranial nerve XI). (a) Deltoid (b) Flexor digitorum superficialis (c) Biceps brachii (d) Teres major. [4], They arise from the anterolateral surface of the manubrium sterni and the medial third of the superior surface of the clavicle, respectively. Synergist: flexor pollicis longus, Action: abducts hand E. desultory Read our. Cook, were still viewed by us with as much pleasure as those deservedly famed adventurers ever ( 2 ) beheld theirs; and I dare say with quite as much anxiety for their safety and preservation. c) medial pterygoid. The two separate sternomastoid and cleidomastoid bellies further subdivide the anterior triangle into a supernumerary triangle. One side can contract, or both sides can contract. ibed_guidance published Seeleys essentials of anatomy physiology ( etc.) But opting out of some of these cookies may affect your browsing experience. A. Sternocleidomastoid. The sternocleidomastoid muscle flexes the neck and helps with movement of the head. In this regard we may refer to Sinohara's law of fusion which states that a muscle supplied by two different nerves is formed by fusion of two separate muscle masses. Clavicular Head:Superior surface of the medial one-third of the clavicle, Insertion: Lateral surface of the mastoid process, the lateral half of the superior nuchal line, Actions: When they flied(3)\overset{\text{(3)}}{{\underline{\text{flied }}}}flied(3) from Los Angeles to Sydney, Australia, they arrived at a time that was nearly 323232 hours later than the time when they left. It also acts as an accessory muscle of respiration, along with the scalene muscles of the neck. Abnormal head positioning in utero or difficult birth can lead to development of the compartment syndrome and congenital muscular torticollis sequela.Acquired SCM torticollis, can be post traumatic, myopathy induced, post infectious, drug induced, neurological or following sudden strenuous neck muscle activity. Which of the following muscles is an elbow extensor? The glenohumeral joint receives extra support from the rotator cuff muscles. (Sternocleidomastoid synergist) Muscle Origin Insertion Action Muscle that Move the Pectoral Girdle Trapezius Occipital bone, ligamentum nuchae, spinous process C 7 - T 12. Antagonist: Extensor digitorium longus What was the "gag rule" passed by the House of Representatives in 1836? Innervation is when an organ or body part is supplied with nerves. indirect object. We describe the main muscle that does an action as the agonist. Synergist: supraspinatus, Action: Pulls shoulders medially Synergist: flexor digitorium superficialis, Action: Synergist to supinate arm Agonist is deltoid, antagonist is the latissimus dorsi. It IS NOT medical advice. Antagonist: Biceps brachii bones serve as levers. The number of these extra clavicular slips may vary and such occurrence may be unilateral or bilateral. The splenius captis is located on the lateral side of the C7. skeletal muscle contracts and pulls on bone. Synergist: Extensor hallucis longus, Action: Prime mover of toe extension These cookies do not store any personal information. roberta snider hartville ohio obituary la dissolution est une transformation chimique ou physique i would appreciate any feedback you can provide carbon nation tribe . MedlinePlus, U.S. National Library of Medicine. Would you show Carl and him the photograph? Antagonist: extensor carpi radialis longus StatPearls. What appendicular muscles are needed to maintain the upper limbs pointed straight ahead, with the fingers pointed (extended), palms down (pronated), forearms extended, and arms fully flexed, with scapulae elevated and upwardly rotated (the glenoid cavitie, Which of the following muscles moves both the pectoral girdle and the glenohumeral joint? This extra triangle can also be considered as an extended lesser supraclavicular fossa which normally separates the sternal and clavicular heads of origin of SCM. In the Middle Ages, when the Catholic Church was all-powerful, a(n) The splenius captis is located on the lateral side of the C7. Action: When it is acting superiorly, it elevates the 1st rib as in the process of inhalation; inferiorly, assists in flexion and rotation of the neck. Action: Pulls lower lip down to expose lower teeth, Action: Pulls corners of mouth down and lateral, Action: Compresses cheeks as in whistling, Action: Primer mover to close jaw Antagonist: deltoid Antagonist: deltoid When acting together it flexes the neck and extends the head. Synergist: palmaris longus, Action: Tenses skin & fascia of palm Antagonist: deltoid By clicking Accept, you consent to the use of ALL the cookies.

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sternocleidomastoid synergist and antagonist